The Science and Research behind EMPowerplus Q96

What is EMPowerplus Q96?

What if I have the MTHFR factor and need Methylated B12 and Folate?

Here are some videos on Micronutrients of the Doctors that were the original researchers of EMPowerplus Q96:

Dr. Charles Popper is a child and adolescent psychiatrist and psychopharmacologist who has been affiliated with McLean Hospital and Harvard Medical School since the late 1970’s. He established and directed the Child and Adolescent Psychopharmacology program at McLean Hospital for 14 years, and taught the first weekly year-long seminar for psychiatic residents in the country on child and adolescent psychopharmacology. He organized the large and popular Course in Child and Adolescent Psychopharmacology at the annual meetings of the American Psychiatric Association for 10 years, and led the Special Interest Study Group on Psychopharmacology at the annual meetings of the American Academy of Child and Adolescent Psychiatry for 12 years.

Dr. Popper was the Founding Editor of the Journal of Child and Adolescent Psychopharmacology, the first journal dedicated to child psychopharmacology and biological child psychiatry, and served as Editor in Chief for 7 years. In recent years, he has been pursuing the potential use of multi-vitamin/multi-mineral supplementation as a primary treatment of bipolar disorder and other psychiatric disorders in children and adults.

Dr. Bonnie Kaplan has been studying developmental disorders in children for many years, especially attention deficit hyperactivity disorder (ADHD), reading disabilities (dyslexia), and motor problems (Developmental Coordination Disorder). She is part of a team from University of Calgary and University of British Columbia, which is searching for the genes that predispose children to develop dyslexia, and is involved in some family studies of reading and attention problems also. With her students, she has been investigating the characteristics of adults with the challenging disorder of ADHD.

Most recently, she has become interested in the mood symptoms that often accompany behavioral disorders, and she has been studying the role of micronutrient supplementation (vitamins and minerals) for the treatment of mood, aggression, and explosive rage. Three publications containing her preliminary work on the supplement have been published, as well as two replications from psychiatrists in the United States. Formal clinical trials are being reviewed in two countries

Julia Rucklidge, PhD is a Professor of Clinical Psychology in the Department of Psychology at the University of Canterbury, Christchurch, New Zealand. Originally from Toronto, she did her training in neurobiology (McGill) and Clinical Psychology (University of Calgary). Her interests in nutrition and mental illness grew out of her own research showing poor outcomes for children with significant psychiatric illness despite receiving conventional treatments for their conditions. For the last 6 years, she has been investigating the role of micronutrients in the expression of mental illness, specifically ADHD, Bipolar Disorder, anxiety and more recently, stress and PTSD associated with the Canterbury earthquakes.

The effectiveness of EMPowerplus™ Q96 as a formula for optimal brain functioning is due to a proprietary, state-of-the-art technology and manufacturing process, as well as the quantities and ratios of the ingredients.

Micronization

A unique micronization technology ensures that the ingredients in Q96 are the perfect size for your body to easily absorb.

Chelation

An extensive 96-hour chelation process wraps the minerals in organic molecules so the body can absorb them and receive the highest possible benefits.

Balance

The minerals and vitamins in Q96 are proportioned in the right ratios for maximum absorption and effectiveness.

Quantity

Q96 provides micronutrients in high enough doses to address nutrient needs and nourish the brain and body.

Here is Tony Stephan telling his whole story about how EMPowerplus Q96 was created and how it help his children and so many others!

ADHD

Moderators of treatment response in adults with ADHD treated with a vitamin–mineral supplement.Rucklidge JJ, Johnsontone J, Gorman B, Boggis A, Frampton CM. Progress In Neuro-Psychopharmacology and Biological Psychiatry. Vol. 50, 3 April 2014, pp. 163-171. Click HERE to read full Report.

Vitamin-mineral treatment of attention-deficit hyperactivity disorder in adults: double-blind randomised
placebo-controlled trial. Rucklidge J, Frampton C, Gorman B, and Boggis A. The British Journal of Psychiatry, January 30, 2014, 113.132126; published ahead of print January 30, 2014. Click HERE to read full Report.

Effect of micronutrients on behavior and mood in adults with ADHD: evidence from an 8-week open label trial with natural extension. Rucklidge J, Taylor M, Whitehead K. Journal of Attention Disorders. 2011 Jan;15(1):79-91. Click HERE to read full Report.

Can Micronutrients Improve Neurocognitive Functioning in Adults with ADHD and Severe Mood
Dysregulation? A Pilot Study. Rucklidge J, Johnstone J, Harrison R. The Journal of Alternative and Complementary Medicine. December 2011, 17(12) 2011, pp. 1125-1131 Click HERE to read full Report.

Anxiety / Stress

Micronutrients reduce stress and anxiety in adults with Attention-Deficit/ Hyperactivity Disorder following a 7.1 earthquake. Rucklidge J, Johnstone J, Harrison R, Boggis A. Psychiatry Research. 189 (2011) 281-287.
Click HERE to read full Report

Shaken but unstirred? Effects of micronutrients on stress and trauma after an earthquake: RCT evidence comparing formulas and doses. Rucklidge J, Andridge R, Gorman B, Blampied N, Gordon H, Boggis A. Hum. Psychopharmacol Clin Exp. 2012; 27: 440–454. Click HERE to read full report.

Post-Earthquake Psychological Functioning in Adults with Attention-Deficit / Hyperactivity Disorder: Positive Effects of Micronutrients on Resilience. Rucklidge J, Blampied N, New Zealand Journal of Psychology. Volume 40, No. 4, 2011: ISSN: 1179-7924. Click HERE

Psychological functioning 1 year after a brief intervention using micronutrients to treat stress and anxiety related to the 2011 Christchurch earthquakes: a naturalistic follow-up. Rucklidge JJ, Blampied N, Gorman B, Gordon HA, Sole E. Hum. Psychopharmacol. Clin. Exp., (2014), 29: 230–243. doi: 10.1002/hup.2392. Click HERE 

Autism

Micronutrients versus standard medication management in autism: a naturalistic case-control study.Mehl-Madrona L, Leung B, Kennedy C, Paul S, Kaplan BJ. Journal of Child and Adolescent Psychopharmacology. 2010 Apr; 20(2):95-103.

Here is a video of a more recent study done in Florida in 2015.

Bipolar Disorder

Nutritional approach to bipolar disorder. Simmons M. Journal of Clinical Psychiatry. 2003 Mar;64(3):338.

ABSTRACT

In a letter to the editor of the Journal of Clinical Psychiatry, Dr. Miles Simmons, a psychiatrist in private practice in Brunswick, Maine, reported his clinical experience with EMPowerplus. Impressed by the striking response of one of his patients to EMPowerplus, Dr. Simmons carefully monitored treatment-resistant patients from his private practice who were willing to try this nutritional approach.

RESULTS: Of 19 patients that met the DSM-IV criteria for bipolar disorder (14 bipolar I and 5 bipolar II), Dr. Simmons observed that “12 of the 19 patients showed marked clinical improvement, 3 showed moderate improvement, and 1 showed mild improvement” (84% positive response rate). Of 16 medicated patients (who were taking 2.7 psychiatric medications on average) 13 were able to completely discontinue their psychiatric medications (over an average of 5.2 weeks) had remained stable on EMPowerplus alone for an average of 13 months.

Do vitamins or minerals (apart from lithium) have mood-stabilizing effects? Popper CW. Journal of Clinical Psychiatry. 2001 Dec;62(12):933-5.

ABSTRACT

Dr. Charles Popper, psychopharmacologist and psychiatrist at Harvard University’s McLean Hospital, published a commentary on the Kaplan et al. (2001) paper, in which he reported the results of his clinical experience with EMPowerplus.

RESULTS: Of 22 patients (10 adults, 9 adolescents, 3 pre-adolescents) who clinically met criteria for bipolar disorder, 19 (86%) showed a positive response to the micronutrient treatment. Of 15 patients taking medications, 11 (73%) were able to gradually withdraw from their medications, and were stable taking the micronutrient treatment alone.

Effective mood stabilization with a chelated mineral supplement: an open-label trial in bipolar disorder.Kaplan BJ, Simpson JS, Ferre RC, Gorman CP, McMullen DM, Crawford SG. Journal of Clinical Psychiatry. 2001 Dec;62(12):936-44.

ABSTRACT

A group of scientists at the University of Calgary and the Alberta Children’s Hospital conducted a study to determine the therapeutic benefit of EMPowerplusTM on 14 unselected adult bipolar patients who had taken psychotropic medications for an average of 6.7 years. Patients were assessed by their own psychiatrists with the Hamilton Rating Scale for Depression (HAM-D), the Brief Psychiatric Rating Scale (BPRS), and the Young Mania Rating Scale (YMRS).

RESULTS: For the 11 patients who completed the minimum 6-month open trial, average symptom reduction was 55% on the HAM-D, 60% on the BPRS, and 66% on the YMRS. The effect size for the intervention was large (>.8) for each measure. The number of psychotropic medications decreased significantly from an average of 2.7 to 1.0. In some cases, the micronutrient treatment replaced psychotropic medications and the patients remained stable. The only reported side effect (i.e., nausea) was infrequent, minor, and transitory.

Multinutrient supplement as treatment: literature review and case report of a 12-year-old boy with bipolar disorder. Frazier EA, Fristad MA, Arnold LE. Journal of Child and Adolescent Psychopharmacology. 2009 Aug;19(4):453-60. Click HERE to read full Report

Database analysis of adults with bipolar disorder consuming a micronutrient formula. Gately D, Kaplan BJ. Clinical Medicine Insights: Psychiatry. 2009 Apr;4:3-16. (2009). 

ABSTRACT

KEY FINDINGS:

• In a large sample of 358 adults with bipolar disorder, the effect size was large at 6 months (0.76, p < 0.001).
• For over half the sample, symptom improvement exceeded 50% at 3 and 6 months.
• One-third of the sample experienced very significant symptom reduction that exceeded 75%.
• The strongest predictors of improved mental health were (a) increasing micronutrient dose 
and (b) decreasing psychiatric medications.

STUDY AIMS: Because of the incomplete benefit from pharmaceuticals and from single nutrient interventions in treating mood symptoms, and the more promising results from multinutrient formulas, the authors investigated the long term benefits of a broad-based micronutrient formula.

DATA SOURCE: The data was obtained from individuals who purchased a micronutrient formula and provide self reported symptom data to the product developers. The database used was anonymous, using assigned identifier numbers. The sample consisted of 682 adults who reported being diagnosed with bipolar disorder. Within that group, 358 individuals reported the single diagnosis of bipolar disorder and provided symptom data for at least 6 months worth of analysis. Neither author was involved in any way with the data collection and could not bias the data in any way.

RESULTS: The analysis showed that not only was the use of the micronutrient formula linked to the outcome but the amount of formula taken (measured in capsules) was directly proportional to the outcome.

Individuals taking medications also experienced significant decreases in symptoms; however, the group with the higher medication index had the more moderate response, and while maintaining the improvement, did not improve like the other groups did. 
The fact that symptom improvements were sustained or even increased at 6 months strongly suggests that the benefit cannot be attributed to a placebo effect.

Selecting for the single disorder makes the participants, and results, comparable to those who are in typical pharmaceutical trials.

People searching for nutritional methods to manage their mood symptoms are likely to have had ineffective experience with medications, and perhaps be considered treatment resistant. While not representative of everyone with bipolar disorder it is possible that they are more difficult to treat, lending more weight to the clinical implications of these findings.

With the emergent evidence of the modest effect of pharmaceuticals and the growing evidence for the improving of mood symptoms using multinutrient formulas, this evidence provides a powerful case for further research with this type of intervention.

This brings to 6 the number of published articles demonstrating reproducibility and efficacy of the Truehope multinutrient formula. Click HERE to read Full Report

Feasibility of a Nutritional Supplement as Treatment for Pediatric Bipolar Spectrum Disorders. Frazier E, Fristad M, Arnold E. The Journal of Alternative and Complementary Medicine: July 2012, 18(7): 678-685. doi:10.1089/acm.2011.0270 Click HERE to read full Report

Database analysis of children and adolescents with bipolar disorder consuming a micronutrient formula.Rucklidge JJ, Gately D, Kaplan BJ. BMC Psychiatry. 2010 Sep 28;10:74. Click HERE to read full Report

Bipolar Disorder and ADHD

Successful Treatment of Bipolar Disorder II and ADHD with a Micronutrient Formula: A Case Study.Rucklidge JJ, Harrison R. CNS Spectrums. 2010 May;15(5):289-95.

ABSTRACT

Bipolar disorder with co-occurring attention-deficit/hyperactivity disorder (ADHD) is a challenge to treat. Ten previous reports have shown potential benefit of a micronutrient treatment (consisting mainly of vitamins and minerals) for various psychiatric symptoms, including mood and ADHD.

This case study aimed to investigate the longer-term impact of the micronutrients on both psychiatric and neurocognitive functioning in an off-on-off-on (ABAB) design with 1 year follow-up. A 21- year-old female with bipolar II disorder, ADHD, social anxiety, and panic disorder entered an open- label trial using a nutritional treatment following a documented 8 year history of on-going psychiatric symptoms not well managed by medications.

After 8 weeks on the formula she showed significant improvements in mood, anxiety, and hyperactivity/impulsivity. Blood test results remained normal after 8 weeks on the formula. She did not report any adverse side effects associated with the treatment. She then chose to come off the formula; after 8 weeks her depression scores returned to baseline, and anxiety and ADHD symptoms worsened. The formula was reintroduced, showing gradual improvement in all psychiatric symptoms.

This case represents a naturalistic ABAB design showing on-off control of symptoms. After 1 year, the patient is now in remission from all mental illness. Neurocognitive changes mirrored behavioral changes, showing improved processing speed, consistency in response speed, and verbal memory. A placebo response and expectancy effects cannot be ruled out although previous poor response to treatment and the duration of the current positive response decrease the likelihood that other factors better explain change.

These consistently positive outcomes alongside an absence of side effects indicate that further research, particularly larger and more controlled trials, is warranted using this multinutrient approach.

Brain Injury

Diet can stimulate functional recovery and cerebral plasticity after perinatal cortical injury in rats. Halliwell C, Kolb B. (2003). Soc Neuro Abs. 29:459-411

Click HERE for full Report

Mood and Behavior Problems

Improved mood and behavior during treatment with a mineral-vitamin supplement: an open-label caseseries of children. Kaplan BJ, Fisher JE, Crawford SG, Field CJ, Kolb B. Journal of Child and Adolescent Psychopharmacology. 2004 Spring;14(1):115-22. Click HERE to read full report

ABSTRACT

A group of scientists from three Alberta universities and the Alberta Children’s Hospital published the results of 11 unselected children with mood and behavior problems. The diagnoses of the children included attention deficit hyperactivity disorder (ADHD), bipolar disorder, oppositional defiant disorder (ODD), obsessive-compulsive disorder (OCD), Asperger syndrome, generalized anxiety disorder (GAD), Prader-Willi Syndrome depression, anxiety, and rage. The children were assessed for a minimum of 8 weeks on an adult dose of EMPowerplus, which was well-tolerated. Outcomes were measured with the Young Mania Rating Scale (YMRS), the Youth Outcome Questionnaire (YOQ), and the Child Behavior Checklist (CBCL).

RESULTS: For all 9 children who completed the trial, the micronutrient treatment was clinically beneficial, and all effect sizes were large (>.8). Improvement was significant on the YOQ (measuring children’s mood, physical symptoms, self-harm behavior, interpersonal relationship problems, social problems, and attention problems), the YMRS (measuring symptoms such as irritability and disruptive aggressive behaviors), and 7 of the 8 CBCL scales (withdrawn behavior, anxious/depressed mood, social problems, thought problems, attention problems, delinquent behavior, and aggressive behavior).

Treatment of mood liability and explosive rage with minerals and vitamins: two case studies in children.Kaplan BJ, Crawford SG, Gardner B, Farrelly G. Journal of Child and Adolescent Psychopharmacology. 2002 Fall;12(3):205-19. Click HERE to read full report

 ABSTRACT

A group of scientists at the University of Calgary and the Alberta Children’s Hospital reported the effects of EMPowerplus on 2 medication-free boys with explosive rage and mood disorders (atypical obsessive-compulsive disorder and pervasive developmental delay), using an ABAB (off-on-off-on) study design.

RESULTS: In both cases, symptoms increased when the micronutrient supplement was withdrawn and improved when the supplement was introduced. When taking the supplement, the boys had fewer emotional outbursts, fewer anxious and obsessional thoughts, more positive mood, and better temper control. Improvements were noted on the Conners Parent Rating Scale (CPRS) mood and temper symptoms, Children’s Version Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) obsessive-compulsive symptoms, and Child Behavior Checklist (CBCL) symptoms of aggressive, delinquent, and anxious/depressed behavior, as well as social and attention problems. Neither boy experienced any adverse effects from taking an adult dose of the nutritional supplement. At the time of publication, both boys had been stable on the nutritional supplement for over 2 years.

OCD (Obsessive Compulsive Disorder)

Successful treatment of OCD with a micronutrient formula following partial response to Cognitive Behavioral Therapy (CBT): a case study. Rucklidge JJ. Journal of Anxiety Disorders. 2009 Aug;23(6):836- 40. Click HERE to read full Report

ABSTRACT

Obsessive Compulsive Disorder (OCD) affects 0.5–2% of young people many of whom are resistant to conventional treatments. This case study describes an 18-year-old male with OCD who first underwent cognitive behavioral therapy (CBT) for a 1-year period with a modest response (his OCD had shifted from severe to moderate). Within a year, his anxiety had deteriorated back to the severe range and he now had major depression. He then entered an ABAB design trial using a nutritional formula consisting mainly of minerals and vitamins (together, known as micronutrients).

After 8 weeks on the formula, his mood was stabilized, his anxiety reduced, and his obsessions were in remission. The treatment was then discontinued for 8 weeks, during which time his obsessions and anxiety worsened and his mood dropped. Reintroduction of the formula again improved the symptoms. This case illustrates the importance of considering the effect micronutrients have on mental illness.

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